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In studies with mouse models of NAFLD and acute kidney injury (AKI), treatment with ACMSD inhibitors increased the transcription of mitochondrial and -oxidation genes, as well as restoring NAD + levels in the kidney and liver 235

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t = 1.29, p = 0.20) (see Supplementary Table 1), where the NAA peak-area SNR is defined as the ratio of the time-domain amplitude of the NAA CH 3 singlet divided by the standard deviation of the noise measured in the last 32 points of the time-domain signal